13
29
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14369 | AZD-0284 | ROR | |
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. | |||
T4050 | GSK2981278 | ROR gama modulator 1 | ROR |
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). | |||
T76775 | Fezakinumab | ILV 094 | Interleukin |
Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related conditions such as psoriasis, rheumatoid arthritis and atopic dermat... | |||
T1955 | SB225002 | CXCR | |
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2. | |||
T77174 | Efmarodocokin alfa | ||
Efmarodocokin alfa, a fusion protein combining human IL-22 with the IgG4 crystallizable fragment, activates IL-22 signaling. This compound has potential applications in the study of severe COVID-19 pneumonia [1]. | |||
T77173 | Eflepedocokin alfa | ||
Eflepedocokin alfa is a recombinant fusion protein that exhibits cell protective activity by comprising human IL-22 fused with the human IgG2-Fc domain. This compound activates the IL-22/IL-22R -mediated signal transduct... | |||
T40043 | RORγt Inverse agonist 10 | ||
RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel... | |||
T76803 | Elsilimomab | ||
Elsilimomab (B-E8), an IgG1 monoclonal antibody targeting interleukin-6 (IL-6), exhibits a dissociation constant (K D) of 22 pM and an inhibitory concentration (IC 50) of 1.4 nM. It is applicable in researching multiple ... | |||
T79170 | Immuno modulator-1 | ||
Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50 values of 4.7 nM and 26 nM, respectively. Additionally, this compound e... | |||
T36011 | P38 MAP Kinase Inhibitor IV | p38 MAPK Inhibitor IV | |
p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α an... | |||
T63559 | IRAK4-IN-22 | ||
IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN... | |||
T81678 | NF(N-Me)GA(N-Me)IL | Amylin (22-27) [NMeG24, NMeI26], human (IAPP) | |
NF(N-Me)GA(N-Me)IL is a biologically active peptide, representing a modified segment (amino acids 22 to 27) of the human islet amyloid polypeptide (hIAPP) sequence NFGAIL. This modification includes N-methylations at G24... | |||
T36629 | Givinostat | ||
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03490 | IL-22 Protein, Human, Recombinant | Human | E. coli |
IL-22 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.9 kDa and the accession number is A0A7R8C389. | |||
TMPY-04973 | IL-22 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
IL-22 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 18.1 kDa and the accession number is A0A7R8C389. | |||
TMPK-00661 | IL-22 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab... | |||
TMPJ-01340 | IL-22 Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 Cells |
IL-22 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 50-65 KDa and the accession number is Q9JJY9. | |||
TMPJ-00062 | IL-22 Protein, Human, Recombinant (hIgG4 hFc) | Human | HEK293 Cells |
IL-22 Protein, Human, Recombinant (hIgG4 hFc) is expressed in HEK293 mammalian cells with C-hIgG4 Fc tag. The predicted molecular weight is 50-75 KDa and the accession number is Q9GZX6. | |||
TMPJ-00061 | IL-22 Protein, Human, Recombinant (hIgG2 hFc) | Human | HEK293 Cells |
IL-22 Protein, Human, Recombinant (hIgG2 hFc) is expressed in HEK293 mammalian cells with C-hIgG2 Fc tag. The predicted molecular weight is 50-62 KDa and the accession number is Q9GZX6. | |||
TMPK-01194 | IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | E. coli |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab... | |||
TMPJ-01339 | IL-22 Protein, Mouse, Recombinant (E. coli) | Mouse | E. coli |
IL-22 Protein, Mouse, Recombinant (E. coli) is expressed in E. coli expression system. The predicted molecular weight is 15 KDa and the accession number is Q9JJY9. | |||
TMPJ-00889 | IL-13 Protein, Mouse, Recombinant (aa 22-131, His) | Mouse | HEK293 Cells |
IL-13 Protein, Mouse, Recombinant (aa 22-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 14-30 KDa and the accession number is P20109. | |||
TMPY-04900 | IL-22BP Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
IL-22BP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55 kDa and the accession number is Q969J5-1. | |||
TMPY-01220 | IL-22BP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-22BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is Q969J5-2. | |||
TMPY-01324 | IL-22BP Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
IL-22BP Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.8 kDa and the accession number is Q969J5-2. | |||
TMPJ-00119 | IL-22RA2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Interleukin-22 Receptor Subunit α-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. I... | |||
TMPK-00512 | IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His) | Cynomolgus | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I... | |||
TMPJ-00076 | IL-28B Protein, Human, Recombinant | Human | HEK293 Cells |
Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to pla... | |||
TMPK-00474 | IL-22RA1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component o... | |||
TMPK-01105 | IL-22RA1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ... | |||
TMPJ-00594 | IL-13 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells |
IL-13 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 22-35 KDa and the accession number is AAK53823. | |||
TMPK-01071 | IL-22RA1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ... | |||
TMPJ-00633 | IL-17F Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
IL-17F Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19-22 KDa and the accession number is G7P4V0. | |||
TMPK-00668 | IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His) | Cynomolgus | HEK293 Cells |
IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by... | |||
TMPK-00986 | IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232... | |||
TMPK-00405 | IL-17RA Protein, Human, Recombinant (aa 33-320, hFc & Avi), Biotinylated | Human | HEK293 Cells |
Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restr... | |||
TMPK-00239 | IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232... | |||
TMPK-00987 | IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232... | |||
TMPK-00238 | IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232... | |||
TMPK-01385 | CRTAM Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of I... | |||
TMPK-00971 | CRTAM Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of I... | |||
TMPK-00487 | E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) | Cynomolgus | HEK293 Cells |
E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response ... |